Clinical Studies & Case Reports
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ACI Medical has clinical testing relationships with some of the best medical research facilities in the world including: Tufts Medical School - Boston, State University of New York - Stony Brook, University of Rochester - New York, Temple University School of Medicine - Philadelphia, Loyola Medical School – Chicago, University of Manitoba, Imperial College of Medicine – London, and Southern Illinois University - Springfield.

Case Reports


 

History and Literature Review

 

Clinical Studies performed using the ArtAssist Device
(* indicates use of other device)

Abstracts are in reverse chronological order.

  1. Nonoperative Active Management of Critical Limb Ischemia: Initial Experience Using a Sequential Compression Biomedical Device for Limb Salvage
    S. Sultan, O. Esan, and A. Fahey.
    Vascular 16, 130-139 (2008)

  2. *Improving Limb Salvage in Critical Ischemia with Intermittent Pneumatic Compression: A Controlled Study with 18-Month Follow-Up
    S.J. Kavros, DPM, K.T. Delis, MD, MS, PhD, FRCSI, EBSQvasc, N.S. Turner, MD, A.E. Voll, RN, D.A. Liedl, RN, P.Gloviczki, MD and T.W. Rooke, MD. Vascular Ulcer and Wound Healing Center, Rochester, Minnesota.
    Journal of Vascular Surgery 47, 543-549 (2008)

  3. Long-term Intermittent Compression Increases Arteriographic Collaterals in a Rabbit Model of Femoral Artery Occlusion
    van Bemmelen, P.S.; Choudry, R.G.; Salvatore, M.D.; Goldenberg, B.I.; and Blebea, J. Departments for Surgery, and Pathology, Temple University, Philadelphia, USA.
    Eur J Vasc Endovasc Surg 34, 340-346 (2007)

  4. Intermittent Pneumatic Compression (IPC) in the Treatment of Peripheral Arterial Occlusive Disease (PAOD) – A Useful Tool or Just Another Device?
    Kalodiki, E. and Giannoukas, A.D. Imperial College, London, UK and Dept. of Vascular Surgery; University of Thessaly Medical School & University Hospital of Larissa, Greece.
    Eur J Vasc Endovasc Surg 33, 309-310 (2007)

  5. Politeal Artery Volume Flow Measurement: A New and Reliable Predictor of Early Patency After Infrainguinal Balloon Angioplasty and Subintimal Dissection
    Ascher E., MD; Hingorani, A.P., MD; and Marks, N.A., MD, RVT. Maimonides Medical Center, Divison of Vascular Surgery.
    J of Vasc Surg, Volume 45, Number 1: 17-24, January 2007

  6. Non-operative Active Management of Critical Lower Limb Ischaemia (CLI): Initial Experience Using a Sequential Compression Biomechanical Device (SCBD) for Acute Limb Salvage in CLI
    Esan, O.; Mahendran, B.; Fahy, A.; Hynes, N.; Tawfink, S.; Zalatel, E.; Sultan, S. Western Vascular Institute, Univeristy Hospital Galway, Ireland.
    Presented at the Society for Clinical Vascular Surgery, Orlando, FL, March 2007 and at the European Society for Vascular Surgery, Prague, September 2006.

  7. A Randomized, Placebo-Controlled Limb Salvage Trial Using the ArtAssist Pneumatic Compression Device
    George Louridas, MD. Univeristy of Manitoba, Winnipeg, Canada.
    Presented at the Winnipeg Vascular & Endovascular Symposium, April 2006.

  8. External Intermittent Compression Increases Collateral Artery Number and Size Following Femoral Artery Occlusion
    vanBemmelen, Paul S.; Choudry, Rashad; Salvatore, Michael D.; Goldenberg, Marat; Goldman, Bruce; Blebea, John. Temple University, Philadelphia, PA .
    Presented at the Society for Vascular Surgery Annual Meeting, 2006. VascularWeb, 2006.

  9. Hemodynamic Effects of Intermittent Pneumatic Compression in Patients with Critical Limb Ischemia
    Labropoulos, Nicos; Leon, Luis R.; Bhatti, Ahmad; Melton, Steven; Kang, Steven S.; Mansour, Ashraf M.; Borge, Marc. The Department of Surgery, Loyola University Medical Center, Maywood Il.
    Journal of Vascular Surgery. October 2005; Volume 42, Number 4: 710-716

  10. Improvement of the Walking Ability in Intermittent Claudication due to Superficial Femoral Artery Occlusion with Supervised Exercise and Pneumatic Foot and Calf Compression: A Randomised Controlled Trial
    Kakkos, S.K.; Geroulakos, G.; Nicolaides, A.N. Imperial College of Science, Technology and Medicine, London, U.K.
    Eur J Vasc Surg. August 2005; Volume 30: 164-175.

  11. Rapid Foot and Calf Compresssion Increases Walking Distance in Patients with Intermittent Claudication; Results of Randomized Study
     Ramaswami, G.; D'Alaya, M.; Hollier, L.; Deutsch, R.; Mcelhinney, A.J. Houston, Tex; Brooklyn and Bronx NY; New Orleans, LA; and San Diego, CA.
    J. Vasc Surg. May 2005; Volume 41, Number 5: 794-801.

  13. Improvement of the Walking Ability in Intermittent Claudification with Supervised Exercise and Pneumatic Foot and Calf Compression: Results at Six Months of a Randomized Controlled Trial
    S Kakkos, G Geroulakos, A Nicolaides.  Vascular Unit, Ealing Hospital and Department of Vascular Surgery Imperial College, London, UK. 
    Presented at the 2004 European Society for Vascular Surgery Annual Meeting.

  14. Intermittent Pneumatic Compression Therapy for Peripheral Arterial Occlusive Disease
    Strejcek, J.; Arkans, E. 
    Phlebology Digest 2004; Volume 17;Issue1:5-8
  15. Improvement in Walking Ability, Ankle Pressure Indices and Quality of Life in Vascular Claudication Using Intermittent Pneumatic Foot and Calf Compression: A Randomized Controlled Trial
     Delis, K.T.; Nicolaides, A.N.; Cheshire, N.J.W; Wolfe, J.H.N.  St. Mary’s Hospital, London, UK. 
    British Journal of Surgery December 2002;Volume88,Issue4:605-606
  16. Haemodynamic Effect of Intermittent Pneumatic Compression of the Leg After Infainguinal Arterial Bypass Grafting
    Delis, K.; Husmann, M.;  Szendro, G.; Peter, N.; Wolfe, J.H.; Mansfield, A.O.  Regional Vascular Center, Surgery and Department of Academic Cardiology, St. Mary’s Hospital, Imperial College School of Medicine, London, UK.
    Br J Surg 2004;91:429-34

  17. Intermittent Pneumatic Calf and Foot Compression Improves Walking Distance in Patients with Claudication: Results of a Randomized Study
    Ramaswami, G.; D'Ayala, M.; Hollier, L.H.; Brem, H.; McElihinney, A.J. Baylor College of Medicine, Houston, TX, New York Methodist Hospital, Brooklyn, NY, Mount Sinai Medical Center, New York, NY, Veterans Adminstration Hospital, Bronx, NY.
    Presented at the 32nd Annual Symposium off Vascular Surgery, Rancho Mirage, CA, March 2004.

  18. Acute Effect of Intermittent Foot-Calf Compression on Skin Microcirculation in Patients with Severe Leg Ischemia
    Ubbink, D. Th.; van Iterson, V.; Lagarnate, D.A. Department of Vascular Surgery, Academic Medical Center, Amsterdam, The Netherlands.

  19. Angiographic Improvement After Rapid Intermittent Compression Treatment (ArtAssist®) for Small Vessel Obstruction
    van Bemmelon, P.; Char, D.; Giron, F; and Ricotta, J.J. Department of Surgery, Division of Vascular Surgery, State University of New York and Stony Brook, NY, USA.
    Ann Vasc Surg 2003;17:224-228
  20. Intermittent Compression Pump for nonhealing Wounds in Patients with Limb Ischemia. The Mayo Clinic Experience (1998-2000)
    Montor, V.M.; Kavros, S.J.; Walsh, E.E.; and Rooke, T.W. Mayo Clinic, Rochester, MN, USA.
    Int Angiol 2002;21:360-6
  21. Enhancing Foot Skin Blood Flux in Peripheral Vascular Disease Using Intermittent Pneumatic Compression: A Controlled Study on Claudicants and Grafted Arteriopaths
    Delis, K.T.; Husmann, M.J.W.; Nicolaides, A.N.; Wolfe. J.H., and Cheshire, N.J., Imperial College School Of Medicine, St. Mary's Hospital, London, UK.
    World Journal Surgery, 2002 Jul;26(7):861-6

  22. Critical Limb Ischemia Successfully Treated by Intermittent Pneumatic Compression
    Yoram Moses, MD and Boris Yoffe, MD, FACS. Department of General and Vascular Surgery, Marailai Medical Center, Ashkelon, Israel.
    IMAJ;Vol4,Issue9,September 2002
  23. Intermittent Pneumatic Compression for the Treatment of lower Extremity Arterial Disease: A Systematic Review
     Labropoulos, Nicos; Wierks, Carls; and Suffoletto, Brian. Department of Surgery, Loyola University Medical Center, Maywood, IL, USA.
    Vascular Medicine 2002;7;141-148
  24. The ArtAssist® Device in Chronic Lower Limb Ischemia
    Louridas, G.; Saadi, R.; Spelay, J.; et. al. Section of Vascular Surgery, the Dept. of Surgery and the Dept. of Rehabilitation Medicine, University of Manitoba, St. Boniface hospital and Health Sciences Centre, Winnipeg, Manitoba, Canada.
    Int Angiol. 2002;21:28-35
  25. Limb Salvage Using High-Pressure Intermittent Compression Arterial Assist Device in Cases Unsuitable for Surgical Revascularization
    van Bemmelen, P.; Gitlitz, D.B.; Faruqi, R.M.; Weiss-Olmanni, J.; Bruneti, V.A; Giron, F.; Ricotta, J.J. Dept. of Vascular Surgery and Podiatry, VA Medical Center, Northport, NY; and the Division of Vascular Surgery, State Univeristy of New York at Stonybrook.
    Arch Surg.     2001; 136:1280-1285

  26. Improvement of the Walking Ability in Intermittent Claudication with Supervised Exercise and Pneumatic Foot and Calf Compression: Preliminary Results at Six Weeks of a Randomized Controlled Study
    Kakkos, S.; Geroulakos, G.; Nicolaides, a.N.; Standfield,N. Vascular Unit, Ealing Hospital and Department of Vascular Surgery Hammersmith Hospital, London, UK.
    Presented at the XI Congress of the Mediterranean League of Angiology and Vascular Surgery, May 30-June 2, 2001. Chicos, Greece
  27. Intermittent Pneumatic Foot & Calf Compression in Vascular Claudication: A Randomized Trial
     Delis, K.T.; Nicolaides, A.N.; Cheshire, N.J.; and Wolfe, J.H. St. Mary's Hospital Imerial College, London, UK.
    Presented at the 29th Annual Symposium on Vascular Surgery, Boca Raton, FL, Åpril 2001

  28. The ArtAssist® Device in Chronic Lower Limb Ischemia. A Pilot Study
    Louridas, G.; Saadia, R.; Spelay, J.; Abdoh, A.; et. al. Sect of Vas. Surg., Dept. of Surg. and Dept. of Rehab Medicine, Univ. of Manitoba, St. Boniface Hospital and Health Sciences Centre, Winnipeg, Manitoba, Canada.
    Presented at the Canadian Vascular Society Meeting, Banff, Alberta, Sept. 2000

  29. Effects of Intermittent Pneumatic Compression of the Calf and Thigh on Arterial Calf Inflow: A Study of Normals, Claudicants, and Grafted Arteriopaths
     Delis, K.T.; Husmann, J.W.; Cheshire, N.J.; and Nicolaides, A.N. Imperial College School of Medicine, St. Mary's Hospital, London, UK.
    Surgery, 2000, Vol. 129, No. 2, p. 188-195

  30. Improvement in Walking Ability, Ankle Pressure Indices and Quality of Life in Vascular Claudication Using Intermittent Pneumatic Foot and Calf Compression: A Prospective Randomized Controlled Trial with 1 Year Follow-Up
    Delis, K.T.; Nicolaides, A.N.; Cheshire, N.J.W.; and Wolfe, J.H.N. Academic Vacular Surgery, St. Mary's Hospital, London, UK.
    Presented at the Vascular Surgical Society of Great Britain & Ireland, Nov. 2000, London Arena

  31. Effect of Intermittent Pneumatic Foot Compression on Popliteal Artery Haemodynamics
    Delis, K.T.; Labropoulos, N.: Nicolaides, A.N.; Glenville, B.; and Standsby, G. Imperial College School of Medicine, Academic Vascular Surgery, St. Mary's Hospital, London UK.
    Eur J Vasc Endovasc Surg, p. 270-277, Vol. 19, No. 3, March 2000

  32. Enhancing Foot Skin Blood Flow in Patients with Infrainguinal Arterial Bypass Grafting Using Intermittent Pneumatic Compression
    Husmann, M.J.W.; Delis, K.T.; Lennox, A.F.; Nicolaides, A.N.; Standsby, G. Irvine Laboratory for Cardiovascular Research, St. Mary's Hospital, London, UK.
    21st Conference in Microcirculation, June 2000

  33. The Acute Effects of Intermittent Pneumatic Foot and Calf Compression on Popliteal Artery Hemodynamics: A Comparative Study
     Delis, K.T.; Nicolaides, A.N.; Labropoulos, N.; and Stansby, G. Imperial College School of Medicine, St. Mary's Hospital, London, UK.
    J Vasc Surg, 2000; 32: 284-92

  34. Improving Walking Ability and Ankle Brachial Pressure Indices in Symptomatic Peripheral Vascular Disease with Intermittent Pneumatic Foot Compression: A Prospective Controlled Study with One-year Follow-up
     Delis, K.; Nicolaides, A.N.; Wolfe, J.H.N.; and Stansby, G. Imperial College School of Medicine, St. Mary's Hospital, London, UK.
    J Vasc Surg 2000;31:650-61

  35. Pneumatic Limb Compression: A Free Lunch? Invited Comments
    Porter, J.M Division of Vascular Surgery, Oregon Health Sciences University.
    J Vasc Surg,     2000;31:821-2

  36. Rapid Intermittent Compression Increases Skin Circulation in Chronically Ischemic Legs with Infra-popliteal Arterial Obstruction
     van Bemmelen, P.S.; Weiss-Olmanni, J. and Ricotta, J.J. Div. of Vascular Surgery, State University of New York, Stony Brook.
    VASA 2000;29:47-52

  37. Effect of Posture on Popliteal Artery Hemodynamics
    Delis, K.T.; Nicolaides, A.N. and Standsby, G. Irvine Lab for Cardiovascular and Investigation and Research, Academic Vascular Surgery, Imperial College School of Medicine, St. Mary's Hospital, London, UK.
    Arch Surg. 2000; 135:265-269

  38. Enhancing Venous Outflow in the Lower Limb with Intermittent Pneumatic Compression. A Comparative Haemodynamic Analysis on the Effect of Foot vs. Calf vs. Foot and Calf Compression
    Delis, K.T.; Slimani, G.; Hafez, H.M. and Nicolaides, A.N. Irvine Lab for Cardiovascular Investigation and Research, Academic Vascular Unit, Imperial College School of Medicine, St. Mary's Hospital, London UK.
    Eur J Vasc Endovasc Surg 19, 250-260; 2000

  39. Optimum Intermittent Pneumatic Compression Stimulus for Lower-limb Venous Emptying
    Delis, K.T.; Azizi, A.A.; Stevens, F.J.G.; Wolfe, J.H.N. and Nicolaides, A.N. Irvine Lab for Cardiovascular Investigation and Research, Academic Vascular Unit, Imperial College School of Medicine, St. Mary's Hospital, London UD.
    Eur J Vasc Endovasc     119, 261-269 (2000)

  40. Case Study and Literature Review: Treatment of Non-healing Lower Extremity Ulcer with a New Form of Progressive, Rapid, Pneumatic Compression
    Shebel, N.D.; Amundsen, D.; and Arkans, E. General Surgery/Section of Vascular Surgery, Kaiser Permanente Medical Center, Panorama City, CA.

  41. Intermittent Foot and Calf Compression. A Novel Way to Treat Intermittent Claudication
    Nicolaides, A.N. Imperial College School of Medicine, St. Mary's Hospital, London UK.
    41st Annual Congress of the International College of Angioogy, Sapporo, Japan; July 1999

  42. Acute Effects of Intermittent Pneumatic Compression on Popliteal Artery Blood Flow
    Labropoulos, N.; Watson, W.C.; Ashraf Mansour, M.; Kang, S.S.; Littooy, F.N.; Baker, W.H. The Department of Surgery, Loyola University Medical Center, maywood, IL.
    Arch Surg. 1998;12:182-186

  43. The Contributions of Arterial and Venous Volumes to Inccreased Cutaneous Blood Flow During Leg Compression
    Eze, A.R.; Cisek, P.L.; Holland, B.S.; Comerota, A.J. Jr.; Veeramasuneni, R.; and Comerota, A.J. Philadephia, Pennsylvania, Charlotte and Gastonia, North Carolina.
    Annals of Vascular Surgery,     1998;12:182-186

  44. Improving Popliteal Artery Flow with Intermittent Pneumatic Foot and Calf Compression
    Delis, K.; Labropoulos, N.; Nicolaides, A.N.; Stansby, G.; and Lumley, J. Irvine Laboratory for Cardiovascular Investigation and Research, Academic Surgical Unit, Imperial College School of Medicine, St. Mary's Hospital, London, UK.

  45. Intermittent Pneumatic Foot and Calf Compression: Determining Its Optimal Effect on Venous Haemodynamics Using Direct Pressure Monitoring
    Delis, K.; Zainal, A.A.; Stevens, R.J.G.; Otah, K.E.; Ibegbuna, V.; and Nicolaides, A.N. Imperial School of Medicine, St. Mary's Hospital, London, UK.
    Presented at the American Venous Forum 10th Annual Meeting; Feb. 1998

  46. Intermittent Foot and Calf Compression: Effects on Arterial Blood Flow and Value in the Treatment of Intermittent Claudication
    Nicolaides, A.N. and Delis, K.
    Presented at the 24th Annual Symposium on Current Critical Problems, New Horizons and Techniques in Vascular and Endovascular Surgery; November 1997

  47. Acute Effects of Intermittent Pneumatic Foot and Calf Compression on Lower Limb Venous Hemodynamics
    Labropoulos, N.; Buckman, J.; Size, G.; and Wightman R. Vascular Diagnostics, Ltd., Parkridge, IL; Division of Surgery, Loyola Medical Center, Maywood, IL.
    Society of Vascular Technology 20th Annual Conference, San Francisco, CA; July 1997

  48. Intermittent Calf and Foot Compression Increases Lower Extremity Blood Flow
    Eze, A.R.; Comerota, A.J.; Cisek, P.L.; Holland, B.S.; Kerr, R.P.; Veeramasuneni, R.; and Comerota, A.J. Jr. Temple University School of Medicine, Philadelphia, PA.
    Presented at the 24th Annual meeting of the Society for Clinical Vascular Surgery; March 1996. Am J Surg; 172:130-135.

    49.
  49. Intermittent Pneumatic Compression Therapy in Patients with Leg Ischemia
    Banga, J.D.; Idzerda, H.H.D.; Schuurman, J.G.; and Eikelboom, B.C. Vascular Center, Academic Hospital Utrecht, The Netherlands.
    Presented at the 17th World Congress International Union of Angiology, London; April 1995

  50. Augmentation of Blood Flow in Limbs with Occlusive Arterial Disease by Intermittent Calf Compression
    vanBemmelen, P.S.; Mattos, M.A.; Faught, W.E.; Mansour, M.A.; Barkmeier, L.D.; Hodgson, K.J.; Ramsey, D.E.; and Sumner, D.S. Springfield, IL.
    Journal of Vascular Surgery 1994; 19:1052-8